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目的评价乳铁蛋白(LF)强化配方奶粉对婴儿生长发育和红细胞指数的影响。方法采用前瞻性多中心对照干预的实验设计,筛选后予以人乳喂养4~6月龄健康足月儿,按门诊顺序分别纳入强化组和对照组,干预3个月。期间两组婴儿分别进行体格指标和血生化指标检测。结果 213名婴儿完成研究,其中强化组115人,对照组98人。干预3个月后强化组和对照组婴儿体重分别为(8 723±245)和(8 558±214)g(P<0.05);年龄别体重Z评分(WAZ)分别为1.02±0.31和0.44±0.18(P<0.05);身高别体重Z评分(WHZ)分别为0.98±0.31和0.41±0.12(P<0.05);血红蛋白为(125.5±15.4)和(116.9±13.1)g/L(P<0.05);血清铁蛋白为(44.7±17.2)和(31.6±18.4)μg/L(P<0.05);同时,干预后强化组贫血和铁缺乏检出率分别为4.35%和13.91%,均明显低于对照组的7.14%和24.49%(P<0.05)。结论添加强化LF配方奶粉干预可以改善人乳喂养婴儿生长发育以及铁营养状况。
Objective To evaluate the effect of lactoferrin (LF) fortified formula on infant growth and erythrocyte index. Methods A prospective multicenter controlled trial was designed. After screening, healthy full-term infants aged 4 to 6 months were fed with breast milk. The patients were enrolled in the intensive group and the control group according to the outpatient order, and were intervened for 3 months. During the two groups of infants were physical indicators and blood biochemical indicators. Results 213 infants completed the study, with 115 in the intensive group and 98 in the control group. The body weight of infants in intensive and control groups were (8 723 ± 245) and (8 558 ± 214) g respectively after 3 months of intervention (P <0.05), and the age-specific weight Z scores were 1.02 ± 0.31 and 0.44 ± 0.18 ± 0.31 and 0.41 ± 0.12, respectively (P <0.05). Hemoglobin was (125.5 ± 15.4) and (116.9 ± 13.1) g / L, respectively ), Serum ferritin were (44.7 ± 17.2) and (31.6 ± 18.4) μg / L, respectively (P <0.05). Meanwhile, the detection rates of anemia and iron deficiency were 4.35% and 13.91% 7.14% and 24.49% in the control group (P <0.05). Conclusion The intervention of intensive LF formula can improve the growth and development of iron in human milk fed infants and the status of iron nutrition.