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目的:探讨依那普利及美托洛尔联合降压对左室舒张功能及左室重构的影响。方法:选择100例左室肥大的高血压病患者随机分为硝苯地平组(Ⅰ组)50例,和联合药物组(Ⅱ组)50例,治疗前及治疗12个月后,观测超声心动图左室舒张末内径(LVD)、室间隔厚度(IVS)、左室后壁厚度(LVPW)、E峰速度、A峰速度及A/E比值,治疗过程中定期进行血压监测,并及时调整剂量。结果:(1)二组治疗12个月后与治疗前A/E比较变化显著(P<0.01);治疗后12个月A/E值同期比较,二组间同期比较也有统计学意义(P<0.05)。(2)LVD、IVS、LVPW、Ⅰ组治疗前与治疗12个月后比较无明显改变(P>0.05);二组治疗前与治疗12个月后有统计学意义(P<0.01),且12个月后Ⅰ组与Ⅱ组间差异亦有统计学意义(P<0.01)。结论:长期应用依那普利及美托洛尔联合降压,可明显改善左室舒张功能及逆转左室重构。
Objective: To investigate the effects of enalapril combined with metoprolol on left ventricular diastolic function and left ventricular remodeling. Methods: A total of 100 hypertensive patients with left ventricular hypertrophy were randomly divided into nifedipine group (n = 50) and combined drug group (n = 50). Before and 12 months after treatment, echocardiography Left ventricular end diastolic diameter (LVD), interventricular septum thickness (IVS), left ventricular posterior wall thickness (LVPW), E peak velocity, A peak velocity and A / E ratio, regular monitoring of blood pressure during treatment and timely adjustment dose. Results: (1) Compared with pre-treatment A / E, the A / E of the two groups changed significantly after 12 months of treatment (P <0.01); A / E of 12 months after treatment also showed statistical significance <0.05). (2) LVD, IVS, LVPW, Ⅰ group had no significant change before and 12 months after treatment (P> 0.05); the two groups before treatment and 12 months after treatment were statistically significant (P <0.01), and After 12 months, the difference between group I and group II was also statistically significant (P <0.01). Conclusion: Long-term use of enalaprol and metoprolol combined with antihypertensive can significantly improve left ventricular diastolic function and reverse left ventricular remodeling.