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目的:分析宫颈活检在宫颈病变检测中的临床应用价值。方法:回顾性分析2007年9月～2010年5月武汉市中心医院门诊就诊行宫颈活检患者3509例病理资料。结果:宫颈癌前病变417例(11.89%),宫颈癌83例(2.37%),癌前病变高发年龄为30～49岁,宫颈癌高发年龄为40～55岁。腺癌12例,占癌症比例14.46%;P16,Ki67染色阳性在正常或炎症宫颈组织、CINⅠ、CINⅡ、CINⅢ分别为25.00%、75.00%、100.00%、100.00%与32.00%、90.00%、100.00%、100.00%。结论:30～49岁年龄段是女性宫颈病变高发年龄段,免疫组化染色可以有效鉴别宫颈良性病变与癌前病变,应积极行宫颈活检明确宫颈病变诊断。
Objective: To analyze the clinical value of cervical biopsy in the detection of cervical lesions. Methods: The clinical data of 3509 cervical biopsy patients from outpatient department of Wuhan Central Hospital from September 2007 to May 2010 were retrospectively analyzed. Results: 417 cases of cervical precancerous lesions (11.89%), 83 cases of cervical cancer (2.37%), precancerous lesions of 30 to 49 years old, high incidence of cervical cancer 40 to 55 years old. Adenocarcinoma in 12 cases, the proportion of cancer accounted for 14.46%; P16, Ki67 positive staining in normal or inflammatory cervical tissue, CINⅠ, CINⅡ, CIN Ⅲ were 25.00%, 75.00%, 100.00%, 100.00% and 32.00%, 90.00%, 100.00% , 100.00%. Conclusions: The age group of 30-49 years old is the female age group with high incidence of cervical lesions. Immunohistochemical staining can effectively distinguish benign cervical lesions from precancerous lesions. Cervical biopsy should be performed to confirm the diagnosis of cervical lesions.