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目的:探讨常规剂量奥美拉唑治疗早产儿喂养不耐受的疗效及对血清胃泌素(gastrin,GAS)的影响。方法:选取60例出现喂养不耐受的早产患儿随机分为2组,对照组30例给予常规处理,治疗组30例在常规治疗基础上于生后第4天开始给予奥美拉唑注射液静脉滴注(0.7mg/kg.d),1次/d,连用5天。采用放射免疫分析法测定治疗组血清胃泌素水平。结果:治疗组胃潴留及腹胀症状消失时间、恢复至出生体重所需日龄、足量胃肠道喂养时间、2周末奶量与对照组比较有显著差异(P<0.01)。治疗组血清GAS水平较对照组明显升高,差异有显著性(P<0.05)。结论:奥美拉唑促进早产儿胃泌素分泌,治疗早产儿喂养不耐受有显著疗效,未见不良反应,为早产儿喂养不耐受的治疗提供了新的治疗方法。
Objective: To investigate the effects of conventional omeprazole on feeding intolerance in preterm infants and its effect on serum gastrin (GAS). Methods: Sixty preterm infants with feeding intolerance were randomly divided into two groups. The control group was given routine treatment. 30 cases in the treatment group were given omeprazole on the fourth day after birth on the basis of routine treatment Liquid intravenous infusion (0.7mg / kg.d), 1 / d, once every 5 days. Serum gastrin levels in the treatment group were determined by radioimmunoassay. Results: The treatment group, gastric retention and disappearance of symptoms of bloating, days to return to birth weight, adequate time for gastrointestinal feeding, milk quantity at 2 weeks and the control group were significantly different (P <0.01). Serum GAS level in the treatment group was significantly higher than that in the control group, the difference was significant (P <0.05). CONCLUSION: Omeprazole can promote the secretion of gastrin in preterm infants, treat the preterm infants with intolerance and have no adverse reactions, and provide a new treatment for the treatment of premature infants with intolerance.