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目的评价沙培林联合顺铂(DDP)治疗恶性腹腔积液的临床效果。方法60例伴有大量腹腔积液的晚期癌症患者,随机分为两组,每组30例。沙培林+DDP组经导管腹腔内注入沙培林和DDP治疗,DDP组仅用DDP治疗。结果沙培林+DDP组完全缓解11例,部分缓解16例,有效率为90.0%,高于DDP组(63.3%)。沙培林+DDP组临床受益率为40.0%,高于DDP组(26.7%)。不良反应主要为发热、恶心、呕吐,患者可耐受。结论沙培林联合DDP治疗恶性腹腔积液疗效明显,不良反应轻,具有一定的临床应用价值。
Objective To evaluate the clinical effect of Sapirin combined with cisplatin (DDP) in the treatment of malignant ascites. Methods Sixty patients with advanced cancer with a large number of ascites were randomly divided into two groups of 30 patients. The Saprenin + DDP group was treated by intraperitoneal injection of Sapirin and DDP, while the DDP group was treated by DDP only. Results In the samplin + DDP group, 11 cases were completely relieved and 16 cases partially relieved. The effective rate was 90.0%, higher than that of the DDP group (63.3%). The clinical benefit rate of samplin + DDP group was 40.0%, higher than that of DDP group (26.7%). Adverse reactions mainly fever, nausea, vomiting, patients can tolerate. Conclusion Sapylin combined with DDP in the treatment of malignant ascites effusion has obvious curative effect and mild adverse reactions, which has certain clinical value.