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目的:探讨不同的服药时间和方法对老年非勺型高血压患者的疗效,为以后临床更好的治疗非勺型高血压患者提供有效的治疗方法。方法:对2014年8月~2015年10月间我院收治的68例老年非勺型高血压患者的临床资料进行回顾性分析,按照门诊就诊序号进行平均分成A、B、C、D四组,A、B组患者分别于每天早7:00和晚7:00服用非洛地平缓释片和厄贝沙坦进行治疗;C组患者采用顿服:于每天早7:00服用非洛地平缓释片和厄贝沙坦,D组患者采用分次服用:每天早7:00服用非洛地平缓释片、晚7:00服用厄贝沙坦,对治疗前后进行24小时动态血压监测。四组患者的治疗效果进行评价,并对不同时间、不同服药方法患者的服药效果进行比较。结果:A、B、C、D四组患者经过治疗后血压昼夜节律异常得到改善,B组改善率明显高于A组,D组改善率明显高于C组,治疗效果显著。结论:对于非勺型高血压患者晚上服用降压药、分次服药更能明显的改善血压昼夜节律异常,起到最佳的降压效果,治疗方法值得临床借鉴和推广使用。
OBJECTIVE: To investigate the curative effect of different medication time and method on elderly patients with non-spoon-type hypertension and to provide an effective treatment for future clinical treatment of patients with non-spoon-type hypertension. Methods: The clinical data of 68 elderly patients with non-dipper hypertensive admitted to our hospital from August 2014 to October 2015 were retrospectively analyzed. According to the outpatient visit number, the patients were divided into four groups: A, B, C and D Patients in group A and group B were treated with sustained-release tablets of felodipine and irbesartan at 7:00 and 7:00, respectively. Patients in group C were treated with Dayton clothing: taking felodipine Sustained-release tablets and irbesartan, D group were taken in groups: taking felodipine sustained-release tablets at 7:00 am and irbesartan at 7:00 pm, and ambulatory blood pressure monitoring 24 hours before and after treatment. The therapeutic effect of four groups of patients was evaluated, and the effect of taking medication in different time and different medication methods was compared. Results: After treatment, the abnormal circadian rhythm of blood pressure was improved in group A, B, C and D, the improvement rate in group B was significantly higher than that in group A, the improvement rate in group D was significantly higher than that in group C, and the treatment effect was remarkable. Conclusion: For patients with non-diphtheria hypertension taking antihypertensive drugs at night, sub-taking medication can significantly improve the abnormal circadian rhythm of blood pressure and play the best antihypertensive effect. The treatment is worthy of clinical reference and promotion.