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目的:通过短期静脉应用丙氨酰-谷氨酰胺,探讨谷氨酰胺(Gln)对慢性阻塞性肺疾病(COPD)呼吸衰竭机械通气患者免疫功能的影响。方法:将40例COPD呼吸衰竭机械通气的患者随机分为干预组和非干预组各20例,两组均给予等热量、等氮静脉营养,干预组添加丙氨酰-谷氨酰胺,同时减少等量氮摄入,并选取COPD缓解期20例作为对照组,比较治疗前及治疗后第7 d免疫学指标。结果:治疗前两组指标无显著差异,但与对照组比较,CD_3~+、CD_4~+、CD_4~+/CD_8~+、IgA均显著下降;治疗后,干预组CD_3~+、CD_4~+、CD_4~+/CD_8~+以及IgA、IgG较治疗前均显著性增加(P<0.05);治疗后两组组间比较有显著性差异(P<0.05)。结论:COPD呼吸衰竭机械通气患者免疫功能明显下降,Gln可增强其免疫功能。
OBJECTIVE: To investigate the effect of glutamine (Gln) on immune function in patients with mechanical ventilation of chronic obstructive pulmonary disease (COPD) respiratory failure through a brief intravenous alanyl-glutamine. Methods: Forty COPD patients with mechanical ventilation of respiratory failure were randomly divided into intervention group and non-intervention group, 20 cases. Both groups were given equal calorie and equal nitrogen nutrition, while the intervention group added alanyl-glutamine while reducing The same amount of nitrogen intake, and selected COPD remission in 20 cases as a control group, before and after treatment on the 7th day immunological indicators. Results: There was no significant difference between the two groups before treatment, but the levels of CD_3 ~ +, CD_4 ~ +, CD_4 ~ + / CD_8 ~ +, , CD_4 ~ + / CD_8 ~ + and IgA, IgG were significantly increased compared with those before treatment (P <0.05). There was significant difference between the two groups after treatment (P <0.05). Conclusion: The immune function of COPD respiratory failure patients with mechanical ventilation is significantly decreased, Gln can enhance its immune function.