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目的:调查癌症患者主要照顾者的心理一致感水平，分析其影响因素，并探讨心理一致感与照顾负荷的关系。方法:采用便利抽样法，选取2018年3月—2019年3月哈尔滨市2所三级甲等医院收治的229名肿瘤患者的主要照顾者为研究对象。采用一般资料调查表、心理一致感量表、癌末照顾负荷量表进行问卷调查，采用n t检验、单因素方差分析、Pearson相关分析、多重线性回归分析对数据进行统计学处理。共发放237份问卷，回收有效问卷229份，有效回收率为96.62%。n 结果:癌症患者主要照顾者的心理一致感得分为（55.67±9.23）分，处于低等水平。单因素分析结果显示，照顾者性别、照顾者职业状况、医疗费用负担状况、患者自理程度、累计照顾时间不同的癌症患者主要照顾者的心理一致感得分差异有统计学意义（n P<0.05）。Pearson相关分析结果显示，癌症患者主要照顾者的心理一致感得分与癌末照顾负荷得分呈正相关（n r＝0.398，n P<0.01）。多重线性回归分析结果显示，医疗费用负担状况、患者自理程度、累计照顾时间、癌末照顾负荷（身心负荷、经济负荷、生活负荷）是癌症患者主要照顾者的心理一致感的主要影响因素（n P<0.05），共同解释了心理一致感32.2%的变异量。n 结论:癌症患者主要照顾者的心理一致感水平较低，且受多种因素的影响，临床医护人员可从患者、照顾者、社会等多方面开展有针对性的干预措施，提升主要照顾者的心理一致感，进而改善患者及其主要照顾者的生活质量。“,”Objective:To explore the sense of coherence in the main caregivers of cancer patients, analyze its influencing factors, and explore the relationship between sense of coherence and care burden.Methods:From March 2018 to March 2019, convenience sampling method was used to select the main caregivers of 229 cancer patients admitted to two ClassⅢ Grade A hospitals in Harbin as the research object. The questionnaire survey was conducted with the General Information Questionnaire, Sense of Coherence Scale (SOC-13) and the Family Caregiver Burden Scale. Statistical analysis was carried out with n t test, single factor analysis of variance, Pearson correlation as well as multiple linear regression. A total of 237 questionnaires were issued and 229 valid questionnaires were returned, with an effective recovery rate of 96.62%.n Results:The score of sense of coherence in main caregivers of cancer patients was (55.67±9.23) , which was at a low level. The results of univariate analysis showed that there were statistically significant differences in the score of sense of coherence in main caregivers of cancer patients with different genders of caregivers, occupational status of caregivers, medical cost burden status, patient self-care level, and cumulative care time (n P<0.05) . The results of Pearson correlation analysis showed that the score of sense of coherence in main caregivers of cancer patients was positively correlated with the care burden score of the terminal cancer (n r=0.398, n P<0.01) . The results of multiple linear regression analysis showed that the burden of medical expenses, the degree of self-care ability of patients, the cumulative care time, and the care burden of end-of-cancer (physical and mental burden, economic burden, life burden) were the main influencing factors of the sense of coherence in the main caregivers of cancer patients (n P<0.05) , which explained 32.2% variation of the sense of coherence.n Conclusions:The main caregivers of cancer patients have a low level of sense of coherence and are affected by many factors. Clinical medical and nursing staff can carry out targeted interventions from patients, caregivers, society and other aspects to enhance the sense of coherence of the main caregivers, thereby improving the quality of life of patients and their main caregivers.