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以加味龙胆泻肝汤联用小剂量氯丙嗪治疗心肝火盛阳性症状为主精神分裂症55例,并与氯丙嗪组作对照。结果:中西医结合治疗组治愈率29.1%,优于氯丙嗪组(X2=4.20,P<0.05)。中西医结合组氯丙嗪每天用量 236.8±41.8 mg,低于氯丙嗪组( t= 9. 11, P<0. 001)。不良反应以锥体外系症状、植物神经系统症状、心血管系统症状多见。中西医结合组震颤、便秘的发生率及不良反应的严重程度均低于氯丙嗪组(P<0.05或P<0.001)。
A total of 55 cases of schizophrenia were treated with Modified Longdan Xiegan Decoction combined with low-dose chlorpromazine for treatment of heart-fire-fire-positive syndrome, and were compared with chlorpromazine group. Results: The cure rate of the combination of TCM and WM was 29.1%, which was better than that of the chlorpromazine group (X2 = 4.20, P <0.05). Chlorpromazine was 236.8 ± 41.8 mg daily in the combined traditional Chinese and western medicine group, which was lower than that in the chlorpromazine group (t = 9.11, P <0.001). Adverse reactions to extrapyramidal symptoms, autonomic nervous system symptoms, cardiovascular system more common symptoms. The incidence of tremor, constipation and the severity of adverse reactions in the Integrative Medicine group were lower than those in the chlorpromazine group (P <0.05 or P <0.001).