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目的观察腺苷蛋氨酸治疗胆汁淤积性病毒性肝炎的疗效。方法１１０例肝内胆汁淤积性病毒性肝炎患者随机分为Ａ（治疗组）、Ｂ（对照组）两组，分别用腺苷蛋氨酸和门冬氨酸钾镁治疗，疗程均为４周。结果腺苷蛋氨酸对淤胆型肝炎皮肤瘙痒的有效率为８６．６７％（１３／１５），与对照组比差异有显著性（Ｐ＜０．０５）；对慢性肝炎合并肝内胆汁淤积患者皮肤瘙痒、纳差的有效率分别为８８．２４％（１５／１７）、８２．３５％（１４／１７），与对照组比差异有显著意义（Ｐ＜００５）。腺苷蛋氨酸治疗后，淤胆型肝炎和急、慢性肝炎合并肝内胆汁淤积患者血清总胆红素（ＳＴＢ）、血清结合胆红素（ＳＣＢ）、总胆汁酸（ＴＢＡ）、ＡＬＴ、ＡＳＴ的降幅明显高于对照组（Ｐ＜０．０５），治疗后ＡＬＰ的下降有显著性意义（Ｐ＜０．０５），ＳＴＢ、ＳＣＢ、ＴＢＡ的复常率显著高于对照组（Ｐ＜０．０５）；淤胆型肝炎和慢性肝炎合并肝内胆汁淤积患者ＡＬＴ的复常率较对照组差异有显著意义（Ｐ＜０．０５）；慢性肝炎合并肝内胆汁淤积患者血清白蛋白在治疗后的增高也有显著性意义（Ｐ＜０．０５）。结论腺昔蛋氨酸治疗胆汁淤积性病毒性肝炎疗效较好，优于门冬氨酸钾镁），没有明显不良反应。
Objective To observe the curative effect of adenosine methionine on cholestatic viral hepatitis. Methods One hundred and ten patients with intrahepatic cholestatic viral hepatitis were randomly divided into A (treatment group) and B (control group) two groups, treated with adenosyl methionine and potassium and magnesium aspartate respectively for 4 weeks. Results The effective rate of adenosyl methionine in the pruritus of cholestatic hepatitis was 86.67% (13/15), which was significantly lower than that in the control group (P <0.05). In patients with chronic hepatitis complicated with intrahepatic cholestasis The pruritus and anorexia rates were 88.24% (15/17) and 82.35% (14/17) respectively, which were significantly different from the control group (P <0.05). After treatment with adenosylmethionine, serum total bilirubin (STB), serum bound bilirubin (SCB), total bile acid (TBA), ALT, AST in patients with cholestatic hepatitis and acute and chronic hepatitis complicated with intrahepatic cholestasis (P <0.05). The decrease of ALP after treatment was significant (P <0.05). The normalization rate of STB, SCB and TBA was significantly higher than that of control group (P <0.05). 05). The normalization rate of ALT in patients with cholestatic hepatitis and chronic hepatitis complicated with intrahepatic cholestasis was significantly higher than that in control group (P <0.05). Serum albumin in patients with chronic hepatitis complicated with intrahepatic cholestasis The increase was also significant (P <0.05). Conclusion adenylmethionine treatment of cholestatic viral hepatitis better than potassium and magnesium aspartate), no significant adverse reactions.