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目的:探讨乳酸清除率（LCR）联合脑电双频指数（BIS）监测在急性重度一氧化碳中毒迟发性脑病（DEACMP）预测中的临床应用价值。方法:收集2017年1月至2019年3月河北医科大学附属哈励逊国际和平医院收治的急性重度一氧化碳中毒患者94例，根据患者出院后60 d内是否发生DEACMP将患者分为DEACMP组（n n=33）和预后良好组（n n=61），比较两组不同时间点LCR、BIS，分析各组LCR与BIS之间的相关性，并应用受试者工作特征曲线（ROC）分析LCR、BIS及二者联合对DEACMP的预测价值。n 结果:DEACMP组在第1 d、3 d、5天的LCR、BIS均明显低于预后良好组，差异有统计学意义（n P <0.05）。Pearson相关分析显示，DEACMP组第1 d、3 d、5天的LCR与BIS之间呈正相关（ n r=0.371，n P<0.05）；预后良好组第1 d、3 d、5天的LCR与BIS之间亦呈正相关（n r=0.373，n P<0.05）。ROC曲线分析显示，LCR、BIS及二者联合预测急性重度一氧化碳中毒（ASCOP）患者发生DEACMP的曲线下面积分别为0.803（95%n CI：0.707~0.897）、0.941（95%n CI：0.886~0.997）、0.949（95%n CI：0.879~1.000）。n 结论:LCR联合BIS对ASCOP患者发生DEACMP有很高预测价值。“,”Objective:The predictive value of LCR and BIS monitoring for delayed encephalopathy in acute severe carbon monoxide poisoning.Methods:Ninety-four patients with acute severe carbon monoxide poisoning treated in the Harrison International Peace Hospital Affiliated to Hebei Medical University between January 2017 and March 2019 were selected. According to whether DEACMP occurred within 60 days after discharge, the patients were divided into the DEACMP group (n n=33) and good prognosis group (n n=61). LCR and BIS of the two groups at different time points were compared, and the correlation between LCR and BIS was analyzed. The predictive value of LCR, BIS and the combination of the two for DEACMP was analyzed by receiver operating characteristic (ROC) curve.n Results:The LCR and BIS of the DEACMP group at day 1t, 3 and 5 were significantly lower than those of the good prognosis group (n P<0.05). Pearson correlation analysis showed that there was a positive correlation between BIS and LCR in the DEACMP group at day 1, 3 and 5 (n r=0.371, n P<0.05). There was also a positive correlation between LCR and BIS in the good prognosis group at day 1, 3 and 5 (n r=0.373, n P<0.05). ROC curve analysis showed that the areas under the curves of LCR, BIS and the combination of the two for predicting the occurrence of DEACMP in patients with ASCOP were 0.803 (95%n CI: 0.707~0.897), 0.941 (95% n CI: 0.886~0.997), and 0.949 (95% n CI: 0.879~1.000), respectively.n Conclusions:LCR combined with BIS is of high predictive value for the occurrence of DEACMP in patients with ASCOP.