肺动脉高压是以小肺动脉的血管增生和重构为主要特征的一种疾病。小肺动脉的血管增生和重构导致肺血管阻力进行性增加,最终引起右心衰竭和死亡。肺动脉高压的治疗越来越受到人们的关注。传统的血管扩张剂在降低肺动脉压的同时,也引起体循环动脉压下降。因此,在肺动脉高压患者的 Pulmonary hypertension is a disease characterized primarily by the proliferation and remodeling of small pulmonary arteries. Vascularization and remodeling of the small pulmonary arteries leads to a progressive increase in pulmonary vascular resistance eventually leading to right heart failure and death. The treatment of pulmonary hypertension has drawn more and more attention. Traditional vasodilators reduce pulmonary arterial pressure, but also cause systemic arterial pressure drop. Therefore, in patients with pulmonary hypertension