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目的:对利巴韦林注射剂严重药品不良反应病例报告的统计、分析,为促进临床用药安全提供参考。方法:采用病例回顾性研究方法对黑龙江省药品不良反应监测数据库中的某时间段收集到的56例利巴韦林注射剂严重药品不良反应报告进进行统计与分析。结果:各年龄段组均有不良反应发生,严重不良反应的主要损害以全身性损害、呼吸系统损害和中枢及外周神经系统损害等为主,其中以过敏性休克、呼吸困难、憋气、喉头水肿等为主要严重不良表现。结论:应加强利巴韦林注射剂的合理使用和监测,以避免不良反应发生,保障人民群众用药安全。
OBJECTIVE: To provide a reference for the statistics and analysis of the reported cases of serious adverse drug reactions of ribavirin injection in order to promote the safety of clinical medication. Methods: A retrospective case-based study of adverse reactions in Heilongjiang Province, the database of adverse drug reactions in the database collected 56 cases of ribavirin serious adverse drug reactions reported to carry statistics and analysis. Results: The adverse reactions occurred in all age groups. The main adverse effects of severe adverse reactions were systemic damage, respiratory system damage and central and peripheral nervous system damage. Among them, anaphylactic shock, dyspnea, suffocation, laryngeal edema As the main serious adverse performance. Conclusion: The rational use and monitoring of ribavirin injection should be strengthened to avoid adverse reactions and ensure the safety of drug users.