目的 :观察大剂量 5-氟脲嘧啶和顺铂联合腹腔灌注治疗胃肠道癌肝转移的疗效。方法 :30例胃肠道癌肝转移患者 ,11例合并腹水 ,常规腹腔穿刺 ,有腹水者放尽腹水 ,注入生理盐水150 0～ 2 0 0 0ml ,5-氟脲嘧啶 150 0mg/ (m2 ·d) ,第 1～ 5天 ;顺铂 80～ 10 0mg/ (m2 ·d) ,第 1天。以 5-氟脲嘧啶 50 0mg/ (m2 ·d) ,静滴 ,第 1～ 5天 ;顺铂 2 0mg/ (m2 ·d) ,静滴 ,第 1～ 5天 ,为对照组。两组均每3周重复 ,3周期后评价疗效。结果 :肝转移癌 :腹腔化疗组有效率 4 3 3% ( 13/ 30 ) ,对照组有效率2 1 4 % ( 6/ 2 8) ,两组有效率差异有显著性 (P <0 .0 5)。癌性腹水 :腹腔化疗组有效率 90 9% ( 10 / 11) ,对照组 37 5% ( 3/ 8) ,两组有效率差异有非常显著性 (P <0 .0 1)。结论 :高剂量 5-氟脲嘧啶和顺铂联合腹腔化疗是治疗胃肠道癌肝转移的有效治疗方法 ,尤其对合并癌性腹水者 Objective : To observe the effect of large doses of 5-fluorouracil and cisplatin combined with intraperitoneal infusion for liver metastasis of gastrointestinal cancer. Methods: Thirty patients with liver metastases from gastrointestinal tract carcinomas, 11 patients with ascites, routine abdominal puncture, ascites were aspirated, 150 ~ 200 ml normal saline solution, and 150 mg/m2 of 5-fluorouracil. d) Day 1 to 5; Cisplatin 80 to 100 mg/(m2 ·d) on the first day. To 5-fluorouracil 50 0 mg / (m 2 · d), intravenous infusion, the first 5 days; cisplatin 20 mg / (m 2 · d), intravenous infusion, the first 1 to 5 days, as the control group. Both groups were repeated every 3 weeks and efficacy was evaluated after 3 cycles. Results: Liver metastatic carcinoma: The efficiency of intraperitoneal chemotherapy group was 433% (13/30), and the control group efficiency was 21.4 % (6/28). There was a significant difference between the two groups (P < .0 5). Cancerous ascites: The effective rate was 90 9% (10/11) in the intraperitoneal chemotherapy group and 37 5% (3/8) in the control group. The difference in efficacy between the two groups was highly significant (P < 0.01). Conclusion : High-dose 5-fluorouracil and cisplatin combined with intraperitoneal chemotherapy is an effective treatment for liver metastasis of gastrointestinal cancer, especially in patients with cancerous ascites