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目的观察加味理中汤结合化疗对晚期胃癌的临床疗效。方法随机选择90例中医辨证属脾胃阳虚的晚期胃癌患者,对照组45例给予口服替吉奥,治疗组45例口服替吉奥基础上服用加味理中汤。对两组患者进行近期疗效和毒副反应的比较。结果近期疗效比较:两组患者治疗后近期疗效比较,治疗组临床获益率高于对照组,差异有显著性(P<0.05)。毒副反应比较:治疗组出现恶心呕吐病例少于对照组(P<0.05),而其他指标比较两组间无明显差异(P>0.05)。结论加味理中汤结合替吉奥治疗中医辨证属脾胃阳虚的晚期胃癌,可提高临床获益率,减轻胃肠道反应,故值得在临床推广。
Objective To observe the clinical effects of Jiaweili Zhong decoction combined with chemotherapy on advanced gastric cancer. Methods A total of 90 patients with advanced gastric cancer with syndrome of spleen-stomach yang deficiency were randomly selected. 45 patients in the control group were given oral Tiagio for treatment. In the treatment group, 45 patients were given Tiaogliu for oral administration. The two groups of patients with short-term efficacy and toxicity compared. The results of the recent efficacy comparison: two groups of patients after treatment of short-term efficacy comparison, the clinical benefit rate was higher than the control group, the difference was significant (P <0.05). Toxic and side effects comparison: The incidence of nausea and vomiting in the treatment group was less than that in the control group (P <0.05), while there was no significant difference in other indexes between the two groups (P> 0.05). Conclusion Jiaweilizhong Decoction combined with Teglitazone for the treatment of advanced gastric cancer with spleen-stomach yang deficiency can improve the clinical benefit rate and reduce the gastrointestinal reaction, so it is worthy of clinical promotion.