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Close coupling calculations have been carried out for rotational excitations in He-H2 collisions with symmetric isotopic substitution (He-H2, D2, T2) and asymmetric isotopic substitution (He-HD, HT, DT). Cross sections have been obtained at the incidence energy of 0.3eV. Based on the calculations, the effect of isotopic substitution on atom-diatom collisions is discussed.