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目的明确实时三维超声技术用于定量颈动脉斑块体积的可行性及准确性。方法采用不同浓度比例的琼脂、明胶和碳化硅颗粒混合物制作成硬度、回声强度各异的含有斑块的血管仿体32个。先后应用11L-3探头和X4探头扫查仿体,并获取仿体的全容积(fullvolume)图像导入TomTec4DCardio-View工作站,由两名超声医师双盲、随机分别在2、4、8、16平面状态下测量体积,其中一位观察者在1月后按此原则再次进行测定。结果在斑块及其回声强度的判断上,实时三维成像与传统二维血管成像具有良好的一致性。2、4、8、16平面状态下所测得的仿体斑块体积与制作过程中的实际体积相比其P值分别为0.001、0.946、0.223、0.196;4、8及16平面测量值与实际体积数值之间的相关系数r分别为0.73、0.82和0.74(P均<0.001)。体积测量数据在观察者间和观察者内部的差异无显著性意义。结论实时三维超声技术可检测颈动脉仿体中存在的斑块,结合TomTec4DCardio-View工作站可准确计算斑块体积。该技术具有较高的可重复性。
Objective To determine the feasibility and accuracy of real-time three-dimensional ultrasound in quantifying carotid plaque volume. Methods A total of 32 plaque-containing vascular fimbriae with different hardness and echogenicity were made by using different concentrations of agar, gelatin and silicon carbide particles. The 11L-3 probe and the X4 probe were successively used to scan the phantom and a full volume image of the phantom was introduced into the TomTec 4DCardio-View workstation, which was double-blindly performed by two sonographers in the 2,4,8,16 plane State measurement volume, one of the observers in January according to the principle of determination again. Results In the judgment of plaque and its echo intensity, the real-time three-dimensional imaging has good consistency with the traditional two-dimensional vascular imaging. The P values of the plaque volume measured in the 2, 4, 8 and 16 planar states were 0.001, 0.946, 0.223 and 0.196 respectively compared with the actual volume in the manufacturing process. The values of the 4, 8 and 16 plane measurements and The correlation coefficients r between the actual volume values were 0.73, 0.82 and 0.74, respectively (all P <0.001). There was no significant difference in volume measurement data between observers and observers. Conclusion Real-time three-dimensional ultrasound detects plaques in the carotid artery phage and the plaque volume can be accurately calculated in combination with the TomTec4DCardio-View workstation. The technology is highly repeatable.