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周围神经损伤修复的黄金标准是自体神经移植,但由于遗留供区部位感觉功能障碍及可供移植神经数量有限,致使该项技术在临床上的应用受到限制,组织工程学的发展为此提供了一种新的解决途径。许旺细胞是周围神经组织工程重要的种子细胞,在神经再生过程中发挥重要作用,移植许旺细胞修复周围神经损伤有广阔的应用前景,但异体移植常面临免疫排斥反应,这些均导致了许旺细胞作为周围神经组织工程的种子细胞在临床应用中受到限制。近年来,随着对具有自我更新和多向分化潜能的间充质干细胞的深入研究,为组织工程化人工神经种子细胞的发展提出新的思路,本文将各种成体干细胞作为许旺细胞的替代细胞的研究进展作一综述。
Peripheral nerve injury repair gold standard autologous nerve graft, but due to the remaining donor site sensory dysfunction and available for a limited number of nerve graft, resulting in the clinical application of the technology is limited, the development of tissue engineering to provide this A new solution. Schwann cells are important seed cells in peripheral nerve tissue engineering and play an important role in the process of nerve regeneration. Transplantation of Schwann cells has broad application prospects in the repair of peripheral nerve injury. However, allogeneic transplantation often faces immune rejection reaction, Wound cells as peripheral nerve tissue engineering of seed cells in clinical applications are limited. In recent years, with the in-depth study of mesenchymal stem cells with self-renewal and multi-directional differentiation potential, and providing new ideas for the development of tissue-engineered artificial neural seed cells, various adult stem cells are used as an alternative to Schwann cells The progress of cell research is reviewed.