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目的 观察培哚普利对糖尿病大鼠肾脏的保护作用。方法 雄性SD大鼠分为正常对照组 (NC)、糖尿病对照组 (DC)、糖尿病培哚普利治疗组 (DP) ,治疗 12周 ,比较各组大鼠尿白蛋白排泄 (UAE)的改变以及肾脏超微结构的改变。结果 DC组UAE显著高于NC组 ,DP组显著低于DC组 ;DC组肾脏超微结构表现为显著的基膜增厚、系膜增生 ,DP组上述改变明显减轻。结论 培哚普利能够对糖尿病大鼠肾脏产生一定保护作用
Objective To observe the protective effect of perindopril on the kidney of diabetic rats. Methods Male SD rats were divided into normal control group (NC), diabetic control group (DC) and perindopril diabetic group (DP) for 12 weeks. The urinary albumin excretion (UAE) As well as changes in renal ultrastructure. Results The UAE in DC group was significantly higher than that in NC group, while the DP group was significantly lower than that in DC group. The renal ultrastructure in DC group showed significant thickening of basement membrane and mesangial proliferation, and the above changes in DP group were significantly reduced. Conclusion Perindopril can play a protective role in the kidney of diabetic rats