近十年来,冠心病的病死率已有显著下降,但AMI存活者的死亡率仍无明显降低。资料表明,心肌梗塞存活者死于再次急性冠状动脉意外者为非冠状动脉疾病的4～8倍。因而,心肌梗塞存活者的猝死和再梗塞的预防则成为当今临床研究的重要课题。 1965年Snow报告心得安可降低心肌梗塞存活者的死亡率,但当时观察病例较少,且无对照。自1974年以来,许多资料表明,AMI存活者给予β受体阻滞剂治疗后,可望降低猝 In the past decade, the mortality rate of coronary heart disease has been significantly reduced, but the mortality of AMI survivors still no significant reduction. Data show that myocardial infarction survivors died of acute coronary artery accidents again non-coronary artery disease 4 to 8 times. Thus, the prevention of sudden death and reinfarction in survivors of myocardial infarction has become an important issue in clinical research. The 1965 Snow report suggests that Encore reduces mortality in survivors of myocardial infarction, but fewer were observed and no controls were available. Since 1974, many data indicate that AMI survivors are expected to reduce the chance of catastrophe after treatment with beta-blockers