苯并咪唑是一类具有广泛生理活性的化合物,许多药物分子中都含有苯并咪唑结构。笔者研究苯并咪唑化合物新的高效合成方法。以邻苯二胺和酮为原料,在微波条件下,经缩合,形成单席夫碱,然后再与其他醛反应,高产率的得到了5个1位、2位接有不同取代基的苯并咪唑化合物。单席夫碱生成咪唑过程中,发生1,3负氢迁移。 Benzimidazole is a class of compounds with a wide range of physiological activity, many drug molecules contain benzimidazole structure. The author of benzimidazole compounds efficient synthesis of new methods. O-phenylenediamine and ketone as raw materials, under microwave conditions, condensation, the formation of a single Schiff base, and then with other aldehydes, with a high yield obtained 5 1, 2 were connected with different substituents of benzene And imidazole compounds. Single Schiff base generated imidazole process, the occurrence of 1,3 negative hydrogen migration.