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目的了解肺癌的不同病理类型与慢性阻塞性肺疾病(COPD)的关系。方法用病例对照的方法,回顾性地分析小细胞肺癌(SCLC)、鳞癌(SQCC)和非小细胞肺癌中除SQCC以外的其他病理类型(nSQCC)肺癌与COPD、慢性支气管炎的关系。结果分别有48.9%(86/176)和30.1%(53/176)的肺癌合并有COPD和慢性支气管炎。与nSQCC患者相比,SCLC和SQCC组合并慢性支气管炎者明显减少(分别为26/62,4/22和23/92;P均<0.05);SQCC组合并COPD者明显增多(19/62 vs 57/92;P<0.05),而SCLC组则无明显差别(10/22;P>0.05)。控制吸烟因素后,仍显示COPD与SQCC明显相关(P<0.05)。结论COPD可能与SQCC的发病相关。
Objective To investigate the relationship between different pathological types of lung cancer and chronic obstructive pulmonary disease (COPD). Methods A case-control study was performed to analyze the relationship between lung cancer and COPD and chronic bronchitis in small cell lung cancer (SCLC), squamous cell carcinoma (SQCC) and non-small cell lung cancer (NSCLC) other than SQCC. Results There were 48.9% (86/176) and 30.1% (53/176) lung cancers with COPD and chronic bronchitis, respectively. Compared with patients with nSQCC, chronic bronchitis was significantly decreased in patients with SCLC and SQCC (26/62, 4/22, and 23/92, respectively; P <0.05); patients with SQCC had significantly higher COPD (19/62 vs 57/92; P <0.05), while there was no significant difference in SCLC group (10/22; P> 0.05). COPD was still significantly associated with SQCC after smoking control (P <0.05). Conclusion COPD may be related to the pathogenesis of SQCC.