二甲苯(Xylene)对人体神经系统的危害已得到公认,但对睾丸毒性作用的研究甚少。本实验采用睾丸组织酶检测、光镜及电镜检查等方法,研究了二甲苯对小鼠睾丸毒性作用。 材料与方法 1.受试物:二甲苯是齐鲁石化公司研究院试剂厂的产品,分析纯。 2.动物分组及染毒:雄性昆明种小鼠,8周龄,体重25～28g,由山东省医学科学院动物房提供。动物随机分为3个染毒组(二甲苯1.25、2.5和8.5g/ Xylene (Xylene) on the human nervous system has been recognized as a harm, but little research on the role of testicular toxicity. In this study, testicular tissue enzyme test, light microscopy and electron microscopy and other methods to study the toxicity of xylene on the testis in mice. Materials and methods 1. The test substance: Xylene is the product of Qilu Petrochemical Company Reagent Factory, which is of analytical grade. 2. Animal groups and exposure: Male Kunming mice, 8 weeks old, weighing 25 ~ 28g, provided by the Animal Hospital of Shandong Academy of Medical Sciences. Animals were randomly divided into three groups (xylene 1.25, 2.5 and 8.5g /