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围产期药理是指药物在妊娠后期至新生儿时期的药理作用,包括药物及其衍生物对发育中机体的影响和机体发育所引起药物代谢方面的改变。1979年5月法国国家与医学研究院总结了近二年来此项研究的成果,归纳为以下三个方面: 一、新概念的提出其一是关于药物诱导酶的机理问题。以苯巴比妥为例,有些作者认为其促进早产儿肝酶系统成熟的作用是通过细胞受体产生的,与类固醇合成蛋白质相似;该药物又能诱导其它酶的活力,后者能改变苯巴比妥本身的作用,发育中机体似可藉以对抗药物中有害成份,这和产生抗体抵御细菌的自卫方
Perinatal pharmacology refers to the pharmacological effects of drugs from late gestation to neonatal period, including the effects of drugs and their derivatives on the developing organism and the changes of the drug metabolism caused by the development of the organism. May 1979 French National Institute of Medicine and Research summarized the results of the study in the past two years, summarized in the following three aspects: First, the new concept of the proposed one is about the mechanism of drug-induced enzyme problem. Take phenobarbital for example, some authors believe that its role in promoting the maturation of the liver enzyme system in preterm infants is through cellular receptors similar to steroid-synthesizing proteins that in turn induce the activity of other enzymes that alter benzene The role of barbiturate itself, the development of the body can be used to fight the harmful ingredients in the drug, which and produce antibodies against bacteria self-defense