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目的 :探讨新生儿窒息患儿血清心肌肌钙蛋白I(cTn -I)水平及临床意义。方法 :采用全自动化学免疫系统检测 4 0例新生儿窒息患儿 (轻度窒息、重度窒息 )血清cTn -I和肌酸磷酸激酶心型同功酶 (CK -MB) ,并与 10例健康新生儿进行对照比较。结果 :各组窒息新生儿血清cTn -I浓度明显升高 ,轻度窒息组、重度窒息组两两之间及与对照组相比均差异显著 (P <0 0 5)。窒息组血清中cTn -I浓度与CK -MB浓度呈显著正相关 (r=0 6 6 9,P <0 0 5)。窒息组中有心血管并发症与无心血管并发症患儿血清cTn -I浓度比较有显著差异 (P <0 0 5) ,且重度窒息组中两者差异更显著 (P <0 0 1)。轻度窒息组和重度窒息组中有心血管并发症组患儿血清cTn -I浓度比较差异显著 (P <0 0 5) ;而无心血管并发症组患儿血清cTn -I浓度相比无显著差异 (P >0 0 5)。结论 :cTn -I可作为新生儿窒息所致急性心肌损伤的辅助诊断指标
Objective: To investigate the serum level of cardiac troponin I (cTn-I) in neonates with asphyxia and its clinical significance. Methods: Serum levels of cTn-I and CK-MB in 40 neonates with asphyxia (mild asphyxia and severe asphyxia) were measured by automatic chemical immunology and compared with 10 healthy controls Newborns for comparison. Results: Serum levels of cTn-I in neonates with asphyxia were significantly higher than those in mild asphyxia group and severe asphyxia group (P <0.05). Ascites serum cTn-I concentration and CK-MB concentration was significantly correlated (r = 0 6 6 9, P <0 05). Serum cTn-I concentrations in children with asphyxia and cardiovascular complications were significantly different (P <0.05), and those in severe asphyxia group were more significant (P <0.01). There was significant difference in serum cTn-I concentrations between children with cardiovascular complications and mild asphyxia group (P <0.05), while there was no significant difference in the level of serum cTn-I between children without cardiovascular complications (P> 0 0 5). Conclusion: cTn-I can be used as a secondary diagnostic indicator of acute myocardial injury caused by neonatal asphyxia