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目的 观察全甲洋参胶囊 (QJYS)对环磷酰胺 (CP)引起的荷瘤小鼠骨髓嗜多染红细胞微核形成 (MNF)和对CP抑瘤作用的影响 ,探讨其临床应用的合理性。方法 以荷瘤 (S180 )小鼠为动物模型 ,分别观察单纯给予不同剂量的QJYS ,单纯给予CP ,同时给予QJYS和CP对小鼠肿瘤生长和骨髓嗜多染红细胞MNF的影响 ,并与对照组进行比较。结果 单纯给予QJYS各剂量组小鼠肿瘤平均重量及MNF均略低于对照组 ,但无显著性差异。单纯给予CP可显著抑制肿瘤的生长 ,但小鼠骨髓MNF由 3 .5‰。上升到 3 2 .1‰ (P <0 .0 0 1)。QJYS与CP同时给药对小鼠的抑瘤效果略好于单纯使用CP ,并可显著降低小鼠骨髓MNF。在QJYS和CP同时给药组中 ,高、中、低剂量QJYS使MNF分别为 2 0 .6‰ ,2 2 .4‰和 2 5 .1‰ ,与CP组比较有非常显著性差异 (P <0 .0 0 1～P <0 .0 5 ) ,呈现良好的量效相关性。结论 QJYS可显著降低CP的致畸毒性 ,减轻烷化剂对DNA的损伤 ,改善CP的抑瘤效果。
Objective To investigate the effect of QJYS capsule on micronucleus formation (MNF) induced by cyclophosphamide (CP) in bone marrow-derived polychromatic erythrocytes in mice and on the antitumor activity of CP, and to explore its rationality of clinical application . Methods Tumor-bearing mice (S180) were used as experimental animal models. QJYS was given to mice in different dosages and given CP alone. QJYS and CP were given to mice for tumor growth and MNF of bone marrow. Compare. Results The mean tumor weight and MNF in mice given QJYS alone were slightly lower than those in control group, but no significant difference was found. Simple administration of CP significantly inhibited tumor growth, but the mouse bone marrow MNF by 3.5 ‰. Rose to 32.1 ‰ (P <0. 001). The anti-tumor effect of QJYS and CP administered at the same time in mice was slightly better than CP alone, and could significantly reduce MNF in mice. In QJYS and CP group, the MNF of high, medium and low doses of QJYS were 20.6%, 22.4% and 25.1%, respectively, which were significantly different from those of CP group (P <0 0 01 ~ P <0 0 5), showing a good dose-effect correlation. Conclusion QJYS can significantly reduce the teratogenicity of CP, reduce the DNA damage of alkylating agents and improve the anti-tumor effect of CP.