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目的 探讨微血管密度 (MVD)、癌基因 (c -erbB -2 /Neu)及雌激素受体 (ER)在无淋巴结转移乳腺癌患者的表达及与预后的关系。方法 选择经手术根治的无淋巴结转移乳腺癌患者 94例 ,检测手术根治后标本中MVD、Neu基因及ER。结果 94例患者MVD 3 5 4± 9 8,Neu基因阳性表达为 44 % ( 4 1/94) ,ER阳性表达为 61% ( 5 8/94)。本组病例 3年内复发 16例 ,复发者其MVD 42 5± 10 6明显高于未复发者 3 1 4± 8 7,P <0 0 5 ,有显著性差异 ;且复发者Neu基因均为阳性表达 ,ER阳性 5例。MVD、Neu基因及ER与复发的关系经直线相关分析提示为 (γ =0 745 ,0 867,P <0 0 1和γ =0 186,P >0 0 5 )。讨论 淋巴结有无转移通常被认为是判断乳腺癌预后的一个重要因素 ,然而淋巴结无转移者仍有部分患者在手术根治后出现复发转移 ,本研究提示MVD、Neu基因是判断无腋淋巴结转移乳腺癌患者预后的重要指标 ,其中MVD计数高并Neu基因阳性的患者预后不良
Objective To investigate the relationship between the expression of MVD, c-erbB-2 / Neu and estrogen receptor (ER) in patients with breast cancer without lymph node metastasis and prognosis. Methods Ninety - four patients with lymph node metastasis undergoing radical operation were selected. MVD, Neu gene and ER were detected in the specimens after radical operation. Results The positive expression of Neu gene was 44% (4 1/94) in 94 patients, and the positive expression of ER was 61% (58/94) in 94 patients. This group of patients relapsed within 3 years in 16 cases, the recurrence of its MVD 42 5 ± 106 was significantly higher than the non-recurrence of 314.47, P <0 05, there was a significant difference; and recurrent Neu genes were positive Expression, ER positive in 5 cases. The relationship between MVD, Neu gene and ER and recurrence was indicated by linear correlation analysis (γ = 0 745, 0 867, P 0 01 and γ 0 186, P 0 05). Discussing lymph node metastasis is usually considered as an important factor to judge the prognosis of breast cancer. However, there are still some patients with lymph node metastasis recurrence and metastasis after radical operation. This study suggests that MVD and Neu gene are useful in determining the metastasis of breast cancer without axillary lymph node metastasis The prognosis of patients with important indicators, including high MVD count and positive Neu gene in patients with poor prognosis