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目的:调查本院门诊抗抑郁药使用情况，为临床合理用药提供参考。方法:本院2018至2020年第一季度门诊开具含抗抑郁药处方8 007张，统计患者的性别、年龄、处方开具科室、临床诊断、各类抗抑郁药处方量等，对抗抑郁药使用合理性进行分析和评价。结果:本院抗抑郁药以50岁以上女性使用为主，50岁以上人群6 773例（84.59%），女性5 568例（69.54%）。8 007张处方中，氟哌噻吨/美利曲辛和选择性5-羟色胺再摄取抑制剂（SSRIs）为临床主要治疗药物，分别为4 130张（51.58%）、3 718张（46.43%）；处方量居前3的科室为神经内科、心内科、消化内科，分别为3 617张（45.17%）、2 887张（36.06%）、1 158张（14.46%）；处方诊断以焦虑或抑郁合并其他疾病为主（6 316张，占78.77%），其中以合并高血压（1 358张，占19.21%）、冠状动脉粥样硬化性心脏病（1 231张，占15.36%）、脑血管病后遗症和脑动脉供血不足（1 222张，占15.25%）、慢性胃炎等消化系统疾病（1 029张，占12.84%）、睡眠障碍（653张，占8.15%）为主。门诊抗抑郁药以单一用药为主（93.16%，7 459/8 007），不合理用药情况严重（25.14%，2 013/8 007），体现在联合用药不适宜（12.24%，980/8 007）、处方诊断不全（8.29%，664/8 007）、给药频次不适宜（4.05%，324/8 007）、单次用量不适宜（0.30%，24/8 007）、给药时机不适宜（0.26%，21/8 007）。结论:本院门诊抗抑郁药处方合理性有待提高，针对这一现象本院正在采取相关措施来提高处方合格率，如提高医生处方质量、提高药师审方能力、嵌入处方前置审核系统，同时加强药师对患者的用药教育及药学监护，以确保用药安全、促进合理用药。“,”Objective:To provide references for clinical rational drug use investigating antidepressants at the outpatient department of our hospital.Methods:A total of 8 007 outpatient prescriptions containing antidepressants issued in the first quarters of 2018 to 2020 at our hospital were included. The patients' gender, age, prescription department, clinical diagnosis, antidepressants' prescription quantity were counted. The rationality of antidepressant use was analyzed and evaluated.Results:Most of the antidepressants at our hospital were used by over 50 years old women. Among the patients who took antidepressants, 6 773 cases (84.59%) were over 50 years old, and 5 568 cases (69.54%) were female. Among the 8 007 prescriptions, 4 130 (51.58%) had flurperthiazide/meritracine and 3 718 (46.43%) had selective serotonin reuptake inhibitors, and they were the main therapeutic drugs at our hospital. The top 3 departments issuing the antidepressants were the departments of neurology (3 617 prescriptions, accounting for 45.17%), cardiology (2 887 prescriptions, accounting for 36.06%), and gastroenterology (1 158 prescritions, accounting for 14.46%). The main diagnosis of the patients of the prescription was anxiety or depression complicated with other diseases (6 316 prescriptions, accounting for 78.77%); the main complications were hypertension (1 358 prescriptions, accounting for 19.21%), coronary atherosclerotic heart disease (1 231 prescriptions, accounting for 15.36%), cerebrovascular disease sequela and cerebral artery blood supply deficiency (1 222 prescriptions, accounting for 15.25%), digestive system diseases such as chronic gastritis (1 029 prescriptions, accounting for 12.84%), and sleep disorder (653 prescriptions, accounting for 8.15%). The prescriptions mainly used one antidepressant, accounting for 93.16% (7 459/8 007). The irrational drug use was serious, accounting for 25.14% (2 013/8 007). The irrational use included irrational combination (12.24%, 980/8 007), incomplete prescription diagnosis (8.29%, 664/8 007), inappropriate drug-use frequency (4.05%, 324/8 007), inappropriate dosage (0.30%, 24/8 007), and inappropriate drug-taking timing (0.26%, 21/8 007).Conclusions:The outpatient antidepressant prescriptions at our hospital are not rational enough, so we should take relevant measures to improve the prescription qualified rate. The measures improving the quality of doctors' prescriptions, improving pharmacists' prescription-checking ability, and embedded prescription-checking system should be taken and pharmacists should strengthen patients' medical education and pharmaceutical care to ensure medication safety and promote rational drug use.