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目的：应用２４ｈ动态血压监测（ＡＢＰＭ）的方法评价氯沙坦治疗原发性高血压的降压疗效、谷／峰比值及药物不良反应。方法：采用开放的方法，５５例原发性高血压患者经１周药物洗脱期，２周安慰剂期后，服用氯沙坦５０ｍｇ，每日一次。 ４周末坐位舒张压≥９０ ｍｍＨｇ者，加量至氯沙坦 １００ｍｇ，每日一次继续服用４周。于安慰剂期末及治疗８周末各行ＡＢＰＭ和实验室检查一次。结果：ＡＢＰＭ结果显示８周末较安慰剂期末于２４ｈ、日间（６：００－２２：００）、夜间（２２：００－６：００）的收缩压／舒张压分别下降（１１．０±９．５／６．８．８±５．８）、（１１．５±１０．８／７．０±６．２）、（１０．２±９．５／６．６±７．０）ｍｍＨｇ。降压Ｔ／Ｐ值ＳＢＰ为７４．５％， ＤＢＰ为７５．５％。有头晕２例，无咳嗽等药物不良反应。结论：氯沙坦５０－１００ｍｇ，每日一次可以维持２４ｈ降压疗效，耐受性好。
OBJECTIVE: To evaluate the antihypertensive effect, peak / peak ratio and adverse drug reaction of losartan in patients with essential hypertension by using 24h ambulatory blood pressure monitoring (ABPM). Methods: Open-label method was used in 55 patients with essential hypertension after one week of drug-eluting period and two weeks of placebo after taking losartan 50 mg once daily. 4 weekend sitting diastolic blood pressure ≥ 90 mmHg were added to losartan 100mg, once daily for 4 weeks. ABPM and laboratory tests were performed at the end of placebo and at the end of 8 weeks of treatment. Results: The results of ABPM showed that systolic blood pressure / diastolic blood pressure were decreased at the end of the 8th weekend compared with the placebo at the end of 24 hours (6: 00-22: 00) and nighttime (22: 00-6: 00) .5 / 6.8.8 ± 5.8), (11.5 ± 10.8 / 7.0 ± 6.2), (10.2 ± 9.5 / 6.6 ± 7.0) mmHg . Buck T / P value of SBP was 74.5%, DBP was 75.5%. Dizziness in 2 cases, no cough and other adverse drug reactions. Conclusion: Losartan 50-100mg, once daily can maintain 24h antihypertensive effect, well tolerated.