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目的观察初诊2型糖尿病早期胰岛素强化治疗的疗效。方法临床对60例入选患者进行早期胰岛素强化治疗2~4周,观察血糖、空腹C肽、FINs、HbA1C和体重指数(BMI)。结果所有观察病例均在2周之内血糖达标,治疗前后血糖、空腹C肽、FINs、HbA1 C和体重指数(BMI)均有明显改善,P均<0.01。结论早期胰岛素强化治疗既降低了血糖,又避免了高胰岛素血症,大大减少了血管并发症的发生,改变了糖尿病的临床进程,减少了糖尿病终末事件的发生,值得临床推广应用。
Objective To observe the effect of early intensive insulin therapy on newly diagnosed type 2 diabetes mellitus. Methods Sixty patients were enrolled in the study. Early insulin therapy was given for 2 to 4 weeks. Blood glucose, fasting C-peptide, FINs, HbA1C and body mass index (BMI) were observed. Results All the observed cases achieved the blood glucose level within 2 weeks. Before and after treatment, the blood glucose, fasting C-peptide, FINs, HbA1 C and body mass index (BMI) were significantly improved, all P <0.01. Conclusions Early intensive insulin therapy not only reduces blood glucose, but also avoids hyperinsulinemia, greatly reduces the incidence of vascular complications, changes the clinical course of diabetes and reduces the occurrence of end-stage diabetes mellitus, which deserves clinical application.