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P2Y_1作为第一个被克隆出来的P2Y受体,由于其分布广泛,在参与对抗炎症、促进血管舒张、阻断动脉粥样硬化,促进神经元和神经纤维细胞生长等生理调节方面,发挥了决定性的作用。所以,P2Y_1作为治疗血栓性疾病和神经性疾病的靶点,越来越受到人们的重视,逐渐成为高通量筛选药物的新靶标。文章介绍了P2Y_1受体的结构、作用机理及其在人体代谢过程中所代表的角色,通过对当前国内外基于P2Y_1受体研发的各种化合物进行归纳、比较、评价,包括中草药中可能通过该受体发挥作用的药物或有效成分,找到了它们各自的优势和缺点,科学的分析未来P2Y_1受体药物发展可能的趋势,包括活性修饰、结构改造等,为将来抗血栓药物的研发提供一点思路和见解。
P2Y_1, as the first cloned P2Y receptor, has played a decisive role in its involvement in the physiological regulation of inflammation, vasodilatation, atherosclerosis, and neuronal and neurofibrillary growth because of its widespread distribution Role. Therefore, P2Y_1, as a target for the treatment of thrombotic diseases and neurological diseases, has drawn more and more attention and gradually becomes a new target of high-throughput screening drugs. This paper introduces the structure and mechanism of P2Y_1 receptor and its role in human metabolism. Based on the current research and development of P2Y_1 receptor, we summarized, compared and evaluated various compounds in Chinese herbal medicine, Receptors play a role in the drug or active ingredient, find their respective advantages and disadvantages, the scientific analysis of the future P2Y_1 receptor drug development trends, including activity modification, structural transformation, for the future development of anti-thrombotic drugs provide a little idea And insights.