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在人体实体瘤中许多经常发生的染色体异常已被描述,几种常见的肿瘤中染色体改变频率最高的是1q三体性和多体性。由于实体瘤的经典细胞遗传学研究通常比较困难,成功率极低,因此用非放射标记的探针进行“原位”杂交是检测间期核中染色体改变特征的适宜方法。生物素标记的探针(L23-21)对人体核型1q12区具有特异性,通常用于孔癌和结
Many frequently occurring chromosomal abnormalities in human solid tumors have been described. The most frequent chromosome changes in several common tumors are trisomy 1q and polysomy. Since classical cytogenetic studies of solid tumors are often difficult and the success rate is extremely low, the use of non-radiolabeled probes for “in situ” hybridization is a suitable method for detecting chromosomal changes in interphase nuclei. Biotin-labeled probe (L23-21) is specific for the human karyotype 1q12 region and is commonly used for cell carcinoma and knots