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目的探讨卵巢核分裂活跃的富于细胞性纤维瘤(MACF)的临床病理学特征、免疫表型、诊断和鉴别诊断。方法对1例卵巢MACF进行形态学观察、免疫组化标记并复习相关文献。结果肿瘤主要由丰富的梭形纤维母细胞样细胞组成,细胞界限不清;细胞核卵圆形至梭形,轻度异型,核分裂象5～9个/10HPF。免疫组化:肿瘤细胞vimentin、α-inhibin、CD56和ER(+),CD34、CD117、Dog-1、CD99、CKpan、EMA、CD10、bcl-2、calretinin、PR、HMB45、S-100、SMA、desmin、H-caldesmon和WT-1(-),Ki-67增殖指数为10%。结论卵巢MACF是一种少见的卵巢纤维性肿瘤,形态学上非常容易误诊为纤维肉瘤,但其生物学行为良性,具有良好的预后,需要长期随访。
Objective To investigate the clinicopathological characteristics, immunophenotype, diagnosis and differential diagnosis of active cytological fibromatosis (MACF) in ovary. Methods One case of ovarian MACF was observed morphologically, immunohistochemically labeled and reviewed. Results The tumors mainly consisted of abundant spindle-shaped fibroblast-like cells with unclear cell boundaries. The nucleus were oval to fusiform and mildly shaped with mitotic figures of 5 to 9/10 HPF. Immunohistochemistry: Vimentin, α-inhibin, CD56 and ER (+), CD34, CD117, Dog- 1, CD99, CKpan, EMA, CD10, bcl- 2, calretinin, PR, , Desmin, H-caldesmon and WT-1 (-), Ki-67 proliferation index was 10%. Conclusion Ovary MACF is a rare type of ovarian fibrous tumor. It is very easy to misdiagnose as fibrosarcoma morphologically, but its biological behavior is benign, has a good prognosis, and needs long-term follow-up.