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目的探讨胃肠道间质瘤的诊治、临床病理学及免疫组织化学特征。方法回顾分析1998~2005年外科收治并经病理证实的22例胃肠道间质瘤(G IST)的临床资料。结果22例均行手术治疗。病理诊断G IST良性6例,交界性3例,恶性13例。免疫组织化学表型CD117阳性19例,CD34阳性18例,V im entin阳性19例,SMA阳性3例,S-100蛋白阳性5例,Desm in阳性3例。随访6~84个月,3例出现远处转移或局部复发,5例死亡。结论G IST缺乏特征性临床表现,术前确诊率较低,其确诊依赖于病理结果与免疫组织化学的结合,手术切除是最有效的治疗手段。
Objective To investigate the diagnosis and treatment of gastrointestinal stromal tumors, clinicopathological and immunohistochemical features. Methods The clinical data of 22 gastrointestinal stromal tumors (G IST) surgically treated and pathologically confirmed from 1998 to 2005 were retrospectively analyzed. Results 22 cases underwent surgical treatment. Pathological diagnosis of GST was 6 cases of benign, borderline in 3 cases, malignant in 13 cases. Immunohistochemical phenotype CD19 positive in 19 cases, CD34 positive in 18 cases, Vim entin positive in 19 cases, SMA positive in 3 cases, S-100 protein positive in 5 cases, Desm in positive in 3 cases. Followed up for 6 to 84 months, distant metastasis or local recurrence occurred in 3 cases, and 5 died. Conclusions G IST lacks characteristic clinical manifestations and the preoperative diagnosis rate is low. The diagnosis depends on the combination of pathological findings and immunohistochemistry. Surgical resection is the most effective treatment.