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目的分析小肠克罗恩病(Crohn’s disease,CD)的CT影像学特征,并探讨多层螺旋CT小肠造影(Multislice computer tomography enterography,MSCTE)用于评估CD活动程度的准确性.方法对53例疑诊CD患者口服阴性对比剂后进行MSCT扫描,后期进行重建,对图像进行分析,并与病理结果对照分析,评价MSCTE用于评估CD活动程度的准确性.经病理证实53例中26例为CD(中度活动10例,重度活动16例).CD的CT表现主要为:病变肠壁黏膜的强化,肠壁厚度的增加、肠系膜纤维脂肪数量的增加、肠系膜脂肪密度升高及肠系膜淋巴结肿大.病变肠壁黏膜的强化及病变肠壁增厚对于鉴别中度与重度CD无明显统计学差异(P=0.631和0.138),而肠系膜纤维脂肪的数量增加、肠系膜脂肪密度升高和肠系膜淋巴结肿大三者对于鉴别CD活动程度具有统计学差异(P=0.009,<0.001和0.045).结论 MSCT是诊断CD一个敏感及非侵入性的成像方法,并可用于评估CD活动程度,MSCTE应作为诊断CD常规的检查方法.“,”Objective To evaluate the MSCT features and its accuracy in determining the degree of activity in patients with Crohn’s disease(CD).Methods 53 cases of patients with clinically suspicious of CD were performed with multi-slice CT imaging with oral solution and three-dimensional images of small intestine were done at the workstation.Compared with pathological results,we evaluated its accuracy in determining the degree of activity in patients with CD.Results 26 of the 53 patients were CD proved by histopathologic.16 patients were histologically diagnosed with severe disease while 10 patients were diagnosed as having moderate disease.There was no significant statistical difference in mucosal enhancement and wall thickening between moderate and severe disease(P=0.631 and 0.138,respectively) whereas engorged vasa recta,fat edema and lymph node enlargement had successfully discriminated between moderate and severe histological findings(P=0.009,<0.001 and 0.045,respectively).Conclusion MSCT enterography is a sensitive and specific non-invasive imaging modality for evaluating the degree of activity of CD,and should be considered in its diagnostic and management algorithms.