摘要目的以组织病理学结果作为参考标准,使用高频和低频超声对脂肪性肝炎大鼠模型的肝脏弹性进行对比。材料与方法本研究获得动物保护委员会的批准。在2014年3—9月期间,将60只雄性SD大鼠分成5组,一组标准饮食喂养4周,其余4组喂养蛋氨酸-胆碱缺乏(MCD)饮食,时间分别为1、4、8和12周,最终建立出不同程度的脂肪性肝炎模型。使用低频(40~130 Hz)和高频(130~220 Hz)超声弹性成像对活体大鼠肝脏的剪切波硬度值进行评估。组织学特性(脂肪变性、炎性和纤维化)和修订的非酒精性脂肪性肝病的 Abstract Objective To compare the liver elasticity of rat model of steatohepatitis with high-frequency and low-frequency ultrasonography using histopathology as a reference standard. Materials and Methods The study was approved by Animal Protection Committee. During the March-September 2014 period, 60 male SD rats were divided into 5 groups, one group fed a standard diet for 4 weeks and the remaining 4 groups fed a M-choline diet for 1, 4, 8 And 12 weeks, eventually establishing a different degree of steatohepatitis model. Shear wave hardness values ​​of living rat livers were evaluated using low-frequency (40-130 Hz) and high-frequency (130-220 Hz) elastography. Histological features (steatosis, inflammatory and fibrotic) and revised non-alcoholic fatty liver disease