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目的:观察三合一疗法联合鲑降钙素注射液(简称鲑降钙素)治疗骨质疏松性腰痛的疗效。方法:将150例患者随机分为3组。治疗1组60例,应用鲑降钙素100U肌肉注射联合三合一疗法:腰痛饮内服加三妙膏贴敷加立体干扰电流刺激贴膏局部皮肤治疗;治疗2组60例,应用鲑降钙素50U肌肉注射联合三合一疗法;对照组30例,只应用鲑降钙素100U肌肉注射治疗。3组均治疗2周,观察3组日本骨科协会腰痛评价表(JOA score)评分、骨代谢:甲状旁腺素(PTH)、降钙素(CT)、血清骨钙素(BGP)、总钙(Ca)、磷(P)、镁(Mg)、尿酸(UA)、碱性磷酸酶(ALP)、酸性磷酸酶(TACP)、非前列腺酸性磷酸酶(NP-ACP)、前列腺酸性磷酸酶(P-ACP)等指标改善情况。结果:治疗后治疗1组、治疗2组的优良率明显高于对照组,差异均有显著性意义(P<0.05);治疗1组与治疗2组间比较,差异无显著性意义(P>0.05)。治疗后治疗1组、治疗2组的PTH下降,CT、BGP上升,与同组治疗前比较,差异有显著性或非常显著性意义(P<0.05,P<0.01);与对照组治疗后比较,差异均有显著性意义(P<0.05);其余各指标3组间治疗前后比较,差异均无显著性意义(P>0.05)。结论:三合一疗法联合鲑降钙素具有较好的治疗骨质疏松性腰痛的作用,疗效优于单用鲑降钙素治疗。
Objective: To observe the curative effect of triple therapy and salmon calcitonin injection (salmon calcitonin) on osteoporotic lumbago. Methods: 150 patients were randomly divided into three groups. Treatment of 1 group of 60 cases, the application of salmon calcitonin 100U intramuscular injection combined with triple therapy: low back pain drink oral plus three Miao paste plus three-dimensional interference current stimulation paste local skin treatment; treatment of two groups of 60 cases, the use of salmon calcine Su 50U intramuscular injection triple therapy; control group of 30 patients, only the application of salmon calcitonin 100U intramuscular injection therapy. Three groups were treated for 2 weeks. JOA score, bone mineral density (PTH), calcitonin (CT), serum BGP (Ca), P, Mg, UA, ALP, TACP, NP-ACP and prostatic acid phosphatase P-ACP) and other indicators to improve the situation. Results: After treatment, the excellent and good rates of treatment group 1 and treatment group 2 were significantly higher than those of control group (P <0.05). There was no significant difference between treatment group 1 and treatment group 2 (P> 0.05). There was significant difference between the two groups (P <0.05, P <0.01) and the control group after treatment (P <0.05). There was no significant difference between the other three groups before and after treatment (P> 0.05). Conclusion: Triple therapy combined with salmon calcitonin has a better effect on treating osteoporosis and lower back pain, and its curative effect is better than that of salmon calcitonin alone.