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目的 探讨肝癌患者体液免疫指标血清球蛋白、IgG、IgA、IgM及补体 3 (C3 )、补体 4(C4)的变化及其与AFP的关系。方法 用自动生化分析仪和放免法定量测定肝癌患者的血清球蛋白、IgG、IgA、IgM、C3、C4及AFP的含量 ,设肝良性疾病肝硬化和正常人两组为对照组 ,运用SPSS软件进行统计。结果 肝癌和肝硬化组的球蛋白、IgG、IgA比正常人明显升高 (P <0 .0 1) ;肝癌组C3比正常人低 (P <0 .0 1) ,C4则高于正常人 (P <0 .0 1) ;AFP阳性和AFP阴性肝癌患者的免疫球蛋白、补体均无差异 (P >0 .0 5 ) ;肝癌患者的AFP与免疫球蛋白、补体无相关性。结论 肝癌患者的体液免疫功能增强 ,AFP与免疫球蛋白、补体无相关性。
Objective To investigate the changes of serum immunoglobulin, IgG, IgA, IgM, complement 3 (C3) and complement 4 (C4) in patients with hepatocellular carcinoma and their relationship with AFP. Methods The contents of serum globulin, IgG, IgA, IgM, C3, C4 and AFP in patients with liver cancer were determined by automatic biochemical analyzer and radioimmunoassay. The liver cirrhosis and normal controls were divided into two groups. Statistics. Results The levels of globulin, IgG and IgA in HCC and cirrhosis group were significantly higher than those in normal people (P <0.01), while in HCC group, C3 was lower than that in normal people (P <0.01) (P <0.01). There was no difference in immunoglobulin and complement between AFP-positive and AFP-negative patients (P> 0.05). There was no correlation between AFP and immunoglobulin and complement in patients with liver cancer. Conclusion The humoral immune function of patients with liver cancer is enhanced. There is no correlation between AFP and immunoglobulin and complement.