本文探讨细胞内药物积聚与细胞抗药性的相关性。MTT法揭示K562r细胞对Dox、Epi、Dau及此三药混合物的IC_(50)分别比K562细胞提高22、16、10及20倍。K562r细胞分别与Dox、Epi或Dau(2—32μg·ml~(-1))温育1h,其细胞内药物含量显著低于K562细胞。但细胞与三药混合物温育1h,二者细胞内药物积聚除3个例外均无显著差异,提示K562r细胞内药物积聚与其药敏无相关性。 This article discusses the correlation between intracellular drug accumulation and cell resistance. MTT assay revealed that the IC 50 of K562r cells against Dox, Epi, Dau and the three drug mixtures were 22, 16, 10 and 20 times higher than K562 cells, respectively. K562r cells were incubated with Dox, Epi, or Dau (2-32 μg·ml -1) for 1 h. The intracellular drug content of K562r cells was significantly lower than that of K562 cells. However, there was no significant difference in the accumulation of intracellular drug accumulation between the two cells and the three drug mixtures for 1 hour, suggesting that there was no correlation between drug accumulation in K562r cells and drug susceptibility.