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目的:探讨血清心肌肌钙蛋白I(cTn I)诊断新生儿缺氧缺血性脑病(HIE)合并心肌损害的临床价值。方法:采用免疫化学发光测定法(CLIA)检测对照组(n=22)、轻度HIE组(n=20)、中度HIE组(n=26)和重度HIE组(n=18)血清cTn I浓度。结果:①在HIE新生儿血清cTnI浓度有明显增高,对照组与轻、中、重度组之间两两比较存在非常显著性差异(P＜0.01);②10例中、重度HIE合并心衰患儿血清cTnI浓度显著增高,其中2例死亡。结论:①cTnI可作为HIE合并心肌损伤新的诊断标准,有助于早期诊断。②cTnI明显增高或许对其预后有一定参考意义。
Objective: To investigate the clinical value of serum cardiac troponin I (cTn I) in the diagnosis of neonatal hypoxic-ischemic encephalopathy (HIE) complicated with myocardial damage. Methods: Serum cTn of control group (n = 22), mild HIE group (n = 20), moderate HIE group (n = 26) and severe HIE group (n = 18) were detected by CLIA. I concentration. Results: (1) Serum cTnI levels in neonates with HIE were significantly higher than those in control group (P <0.01). (2) In 10 cases of moderate and severe HIE complicated with heart failure Serum cTnI concentrations were significantly higher, of which 2 died. Conclusion: ① cTnI can be used as a new diagnostic criteria for HIE with myocardial injury, contribute to early diagnosis. ② cTnI significantly higher prognosis may have some reference value.