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目的介绍药物超敏反应综合征的发病机制、临床特点及诊疗方法。方法报道1例早产儿药物超敏反应综合征的发病原因、临床表现、实验室检查及治疗方法,并进行文献复习。结果本例早产儿诊断为败血症、化脓性脑膜炎,在使用抗生素2周和第2次输血后分别出现皮疹,以及血液、呼吸、肝脏、循环等多系统损害,应用激素和丙种球蛋白治疗后症状缓解,好转出院。结论药物超敏反应综合征是由感染和药物过敏引起的一种迟发型超敏反应,以发热、皮疹及多器官损害为特点,在新生儿期罕见。治疗关键在于早期停用致敏药物,联合应用激素和丙种球蛋白。
Objective To introduce the pathogenesis, clinical features and diagnosis and treatment of drug hypersensitivity syndrome. Methods The incidence, clinical manifestations, laboratory tests and treatment of drug hypersensitivity syndrome in 1 premature infants were reported and reviewed. Results This case of premature infants diagnosed as sepsis, purulent meningitis, rashes occurred after two weeks of antibiotics and the second blood transfusion, and blood, respiratory, liver, circulatory and other multi-system damage, the application of hormones and gamma globulin after treatment Symptoms, improve discharge. Conclusions The drug hypersensitivity syndrome is a delayed type hypersensitivity reaction caused by infection and drug allergy. It is characterized by fever, rash and multiple organ damage, and is rare in the neonatal period. The key is the early treatment of sensitization drugs, the combination of hormones and gamma globulin.