类风湿性关节炎(RA)的免疫疗法一般分为免疫抑制和免疫增强两部分。一、免疫抑制疗法(一) 免疫抑制剂治疗RA的免疫抑制剂主要为烷化剂中的环磷酰胺(CYP)和抗代谢剂中的硫唑嘌呤(AZP)。1.作用机制:CYP对B淋巴细胞的抑制作用较强,但长期使用后,对T淋巴细胞也有抑制作用。AZP对T淋巴细胞的抑制作用较强,对B淋巴细胞的抑制作用较弱。但治疗RA Immunotherapy of rheumatoid arthritis (RA) is generally divided into immunosuppression and immune enhancement in two parts. First, the immunosuppressive therapy (A) Immunosuppressive agents for the treatment of RA immunosuppressive agents are mainly alkylating agents cyclophosphamide (CYP) and anti-metabolite azathioprine (AZP). 1. Mechanism of action: CYP inhibition of B lymphocytes stronger, but after long-term use, T lymphocytes also inhibited. AZP has a strong inhibitory effect on T lymphocytes and a weak inhibitory effect on B lymphocytes. But treat RA