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目的：探讨腹腔镜技术修补溃疡病穿孔的安全性和疗效。方法2011年1月~2015年6月行胃十二指肠溃疡穿孔修补患者112例﹐其中腹腔镜下修补63例﹐开腹手术修补49例﹐对照两组患者的手术和术后情况。结果两组患者均无围手术期死亡﹐腹腔镜组有3例中转开腹手术。腹腔镜组和开腹组平均手术时间分别为(74.85±15.8)min和(62.97±12.14)min﹐差异有统计学意义(<0.001)。开腹组患者术后使用镇痛剂的比例显著高于腹腔镜组(<0.001)。两组患者术后腹腔脓肿﹑修补处漏﹑肺部感染发生率以及住院时间均无统计学显著差异。结论腹腔镜下修补胃十二指肠溃疡穿孔有效﹑安全﹐具有较高的临床应用价值。“,”Objective To explore the safety and efficacy of laparoscopic repair of the perforated gastroduodenal ulcer. Methods Between January 2011 and June 2015, we identified 112 patients with perforated peptic ulcer, among them, 63 cases repaired by laparoscopy and 49 cases treated by open method. The clinic data of the two groups were compared. Results There were no death in two groups, three cases converted to open operation. The mean operation time of laparoscopic group and open group were(74.85±15.8)min and(62.97±12.14)min respectively( <0.001). Open group had a significantly higher proportion of patients received analgesics than laparoscopic group ( <0.001). There were no significant difference between the two groups in the rate of intra-abdominal abscess, leakage of the repaired side, pulmonary infection and hospital stay. Conclusion Laparoscopic repair of the perforated gastroduodenal ulcer is effective and safe, and have high application value.