论文部分内容阅读
观察卡托普利（Ｃａｐ）对血浆血栓素Ａ２（ＴＸＡ２）、前列腺环素（ＰＧＩ２）及血小板胞浆钙离子浓度（［Ｃａ２＋］ｉ）、血小板聚集率（ＰＡｇ）的影响．方法：大鼠管饲Ｃａｐ１００ｍｇ·ｋｇ－１·ｄ－１，２ｗｋ．结果：二肾一夹型肾血管性高血压大鼠血浆血管紧张素Ⅱ（Ａｎｇ）和ＴＸＡ２／ＰＧＩ２升高（Ｐ＜００５），血小板［Ｃａ２＋］ｉ及ＰＡｇ显著增高（Ｐ＜００１）．Ｃａｐ在显著降低血压同时，血浆ＴＸＡ２／ＰＧＩ２显著降低（Ｐ＜００５），且血小板［Ｃａ２＋］ｉ及ＰＡｇ也明显降低（Ｐ＜００１）．结论：Ｃａｐ对血小板［Ｃａ２＋］ｉ及血小板功能的影响与其改善ＴＸＡ２／ＰＧＩ２比值有关．
To observe the effect of Cap on plasma TXA2, PGI2 and platelet cytosolic Ca2 + concentration and platelet aggregation rate (PAg). Methods: Rats were administered Cap100mg · kg-1 · d-1, 2wk. Results: Plasma levels of angiotensin Ⅱ (Ang) and TXA2 / PGI2 (P <005) and platelet [Ca2 +] i and PAg were significantly increased in two-kidney-clip type renovascular hypertensive rats 01). Cap significantly decreased TXA2 / PGI2 (P <005) and decreased platelet [Ca2 +] i and PAg (P <001). Conclusion: The effect of cap on platelet [Ca2 +] i and platelet function is related to the improvement of TXA2 / PGI2 ratio.