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目的:探讨细胞因子TNF-a、IL-6异常表达对输卵管性不孕患者的影响。方法:选取2012年9月至2013年8月因“不孕”在本院行腹腔镜手术治疗的病例45例作为视察组和因“子宫肌瘤及卵巢良性肿瘤”行腹腔镜手术患者47例作为对照组。采用酶联免疫法(Elisa法)测定两组患者腹腔液中TNF-a、IL-6水平。结果:对照组中TNF-a、IL-6水平明显高于观察组(P<0.05)。结论:细胞因子TNF-a、IL-6水平在输卵管性不孕患者中的表达异常升高,其细胞毒性可能导致输卵管性不孕发生。
Objective: To investigate the effect of abnormal expression of cytokines TNF-a and IL-6 on tubal infertility patients. Methods: From September 2012 to August 2013, 45 cases of “Infertility” underwent laparoscopic surgery in our hospital were selected as the observation group and under the laparoscopy of “Uterine fibroids and benign ovarian tumors” 47 cases of surgical patients as a control group. The levels of TNF-a and IL-6 in peritoneal fluid of the two groups were measured by enzyme-linked immunosorbent assay (Elisa method). Results: The levels of TNF-a and IL-6 in the control group were significantly higher than those in the observation group (P <0.05). Conclusion: The expression of cytokines TNF-a, IL-6 in patients with tubal infertility abnormally increased, and their cytotoxicity may lead to tubal infertility.