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在２４３例中国人中研究两个糖代谢途径限速酶基因，己糖激酶Ⅱ基因（ＨＫ２，骨胳肌）及磷酸烯醇式丙酮酸羧激酶基因（ＰＣＫ１，肝）的微卫星多态性及与非胰岛素依赖型糖尿病（ＮＩＤ－ＤＭ）的关系。结果表明：（１）普通群体中，ＨＫ２微卫星多态标志等位基因频率在不同地区中国人群体间及中国人与白种人间无差异；（２）ＰＣＫ１频率在不同地区中国人群体间无差异，但中国人与白种人间存在差异；（３）中国人ＮＩＤＤＭ全组及亚组与相应对照组比较中，ＨＫ２频率无差异；（４）ＰＣＫ１等位基因频率在糖尿病家族史及起病年龄亚组比较中存在差异。揭示：（１）ＨＫ２与中国人ＮＩＤＤＭ无关联；（２）ＰＣＫ１与中国人ＮＩＤＤＭ部分亚群有关。
Two hundred and seventy-four Chinese were studied for microsatellite polymorphisms of the two rate-limiting enzymes of glucose metabolism, the hexokinase II gene (HK2, skeletal muscle), and the phosphoenolpyruvate carboxykinase gene (PCK1, liver) And its relationship with non-insulin-dependent diabetes mellitus (NID-DM). The results showed that: (1) In the general population, the allele frequency of microsatellite polymorphism marker HK2 was not different between Chinese population and between Chinese population and Caucasian population in different regions; (2) The frequency of PCK1 in Chinese population was no (3) There was no difference in the frequency of HK2 among Chinese NIDDM patients and the corresponding control group; (4) The frequency of PCK1 alleles was significantly higher in the family history and onset of diabetes There are differences in age subgroups. Reveal: (1) HK2 is not associated with Chinese NIDDM; (2) PCK1 and Chinese NIDDM subsets related.