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目的观察环磷酰胺冲击疗法(CTX-PT)治疗小儿难治性肾病(RNS)的临床疗效。方法RNS共77例,随机分为治疗组38例,对照组39例。治疗组接受CTX治疗,每2周1次,总累积量为100~150 mg/kg。对照组用环孢素(Cys A),每天5~6 mg/kg,1个月为1个疗程。结果治疗组与对照组平均缓解期分别为(10.7±3.3)和(35.3±2.9)个月,缓解率分别为76.3%和33.3%,两组比较差异有显著性(均P<0.01)。结论环磷酰胺冲击治疗具有方法简便,费用低廉,可明显降低肾病综合征的复发,不良反应少,值得临床推广。
Objective To observe the clinical efficacy of cyclophosphamide (CTX-PT) in the treatment of children with refractory renal disease (RNS). Methods A total of 77 RNS patients were randomly divided into treatment group (38 cases) and control group (39 cases). The treatment group received CTX treatment once every 2 weeks with a total cumulative volume of 100-150 mg / kg. Control group with cyclosporine (Cys A), 5 ~ 6 mg / kg, 1 month for a course of treatment. Results The average remission rates of the treatment group and the control group were (10.7 ± 3.3) and (35.3 ± 2.9) months, respectively, and the remission rates were 76.3% and 33.3% respectively. There was significant difference between the two groups (all P <0.01). Conclusion The impact of cyclophosphamide therapy has the advantages of simple method, low cost, can significantly reduce the recurrence of nephrotic syndrome, adverse reactions, worthy of clinical promotion.