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本世纪60～70年代报告洋地黄中毒发生率为6～23%,死亡率高达41%。近年由于对地高辛药代动力学和生物利用度的进一步了解,维持量的减少,地高辛血清浓度测定的应用,以及对药物相互作用的认识,洋地黄中毒的发生率已明显减少。本文回顾性研究地高辛中毒诊断的准确性、发生率与死亡率。方法:复习本所大型城市教学医院1980～1988年间出院诊断为洋地黄中毒的全部病历及1987年注院的994份心力衰竭病历。按下述标准分为:肯定中毒——患者有提示地高辛中毒的症状和/或心律失常,并在停用地高辛后消失;可能中毒——
In the 1960s and 1970s, the incidence of digitalis poisoning was 6-23% and the mortality rate was as high as 41%. In recent years, the incidence of digitalis poisoning has been significantly reduced due to the further understanding of digoxin pharmacokinetics and bioavailability, the reduction of maintenance dose, the application of digoxin serum test, and the understanding of drug interactions. This article retrospectively studies the accuracy, incidence and mortality of digoxin poisoning diagnosis. Methods: To review all medical records of digitalis diagnosed as digitalis poisoning during 1980-1988 in our large city teaching hospital and 994 medical records of heart failure admitted to hospital in 1987. According to the following criteria are divided into: affirmed poisoning - patients have been prompted to digoxin symptoms and / or arrhythmia, and disappeared after the disable digoxin; possible poisoning -