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目的:观察甘草泻心汤联合地塞米松粘贴片治疗复发性口腔溃疡(ROU)的临床疗效。方法:将74例患者随机分为2组各37例。2组均予以维生素C、维生素B2等治疗,西医组患者予以地塞米松粘贴片,中西医组在西医组治疗基础上加用甘草泻心汤口服,观察临床疗效并随访复发情况。结果:临床总有效率中西医组为91.89%,西医组为72.97%,2组比较,差异有统计学意义(P<0.01)。治疗后随访6月和1年,中西医组分别复发6例(17.65%)和10例(37.04%),西医组分别复发11例(32.35%)和15例(55.56%),中西医组复发率低于西医组(P<0.05)。结论:甘草泻心汤联合地塞米松粘贴片治疗ROU的疗效明显优于单纯的地塞米松粘贴片治疗,能缩短溃疡复发的间歇时间,减少溃疡数量,并能预防其复发,降低复发率。
Objective: To observe the clinical efficacy of Gancao Xiexin Decoction combined with dexamethasone adhesive patch in the treatment of recurrent oral ulcer (ROU). Methods: 74 patients were randomly divided into two groups of 37 cases. 2 groups were treated with vitamin C, vitamin B2 and so on. Western medicine group was given dexamethasone sticking tablets. Western medicine group was treated with western medicine group with Gancaoxiexin decoction orally to observe clinical curative effect and follow-up recurrence. Results: The total clinical effective rate was 91.89% in Western medicine group and 72.97% in Western medicine group. The difference between the two groups was statistically significant (P <0.01). Six months and one year follow-up in the treatment group, 6 cases (17.65%) and 10 cases (37.04%) in the Western medicine group relapsed respectively, and 11 cases (32.35%) and 15 cases (55.56% The rate was lower than that of western medicine group (P <0.05). Conclusion: The therapeutic effect of Gancaixiexin Decoction combined with dexamethasone adhesive patch on ROU is obviously better than that of simple dexamethasone adhesive patch, which can shorten the intermittent time of ulcer recurrence, reduce the number of ulcer, prevent its recurrence and reduce the recurrence rate.