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目的:观察益气活血方联合奥美拉唑治疗消化性溃疡的疗效及治疗前后三叶因子Ⅱ(TFF2),血管内皮细胞生长因子(VEGF)的变化。方法:103例经明确诊断为消化性溃疡患者,随机按数字表法分为观察组52例和对照组51例,对照组服用奥美拉唑胶囊,20 mg/次,2次/d;观察组在对照组治疗的基础上服用益气活血方,两组疗程均为3个月,观察临床中医证候积分,TFF2,VEGF水平及1年复发率。结果:观察组中医证候总有效率为94.23%高于对照组的82.35%,具有统计学意义(P<0.05)。观察组胃镜疗效总有效率为82.69%,对照组总有效率为86.27%,两组比较不具有统计学意义。两组中医证候积分均较治疗前明显下降(P<0.05),观察组比对照组下降明显,具有统计学意义(P<0.05)。两组TFF2,VEGF表达水平均较治疗前明显提高(P<0.05),观察组比对照组改善更为显著(P<0.05)。治疗3个月后,治疗组Hp感染转阴率为73.5%,对照组Hp感染转阴率为65.6%,两组Hp感染转阴率不具有统计学意义。观察组1年内复发8例,对照组1年内复发22例,两组1年内复发率比较具有显著性差异(P<0.05)。结论:益气活血方联合奥美拉唑胶囊较单纯应用奥美拉唑胶囊疗效显著,且能提高TFF2,VEGF表达水平,降低1年内复发率。
Objective: To observe the curative effect of Yiqi Huoxue Decoction combined with omeprazole on peptic ulcer and the change of TFF2 and VEGF before and after treatment. Methods: A total of 103 patients diagnosed as peptic ulcer were randomly divided into observation group (n = 52) and control group (n = 51) according to the digital table method. The control group was given omeprazole capsules (20 mg twice daily) The patients in the control group took Yiqi Huoxue prescription on the basis of the control group. The two courses of treatment were 3 months. The scores of clinical TCM syndromes, TFF2, VEGF and 1-year recurrence rate were observed. Results: The total effective rate of TCM syndromes in the observation group was 94.23% higher than that in the control group (82.35%), with statistical significance (P <0.05). The total effective rate of gastroscopy in observation group was 82.69%, while the total effective rate in control group was 86.27%. There was no statistical significance between the two groups. The scores of TCM syndromes in both groups were significantly lower than those before treatment (P <0.05), and the observation group decreased significantly compared with the control group (P <0.05). The expression of TFF2 and VEGF in both groups were significantly higher than those before treatment (P <0.05), and the observation group was more significant than the control group (P <0.05). After 3 months of treatment, the Hp infection negative rate was 73.5% in the treatment group and 65.6% in the control group. The negative rate of Hp infection in the two groups did not reach statistical significance. In the observation group, 8 cases relapsed in 1 year and 22 cases in the control group within 1 year. There was significant difference (P <0.05) between two groups in recurrence rate within 1 year. Conclusion: The combination of Yiqi Huoxue recipe and omeprazole capsule is more effective than omeprazole capsule alone, and can increase the expression of TFF2 and VEGF and reduce the recurrence rate within one year.